Simvastatin Attenuates Experimental Cerebral Vasospasm and Ameliorates Serum Markers of Neuronal and Endothelial Injury in Patients After Subarachnoid Hemorrhage: A Dose-Response Effect Dependent on Endothelial Nitric Oxide Synthase

نویسندگان

  • Matthew J. McGirt
  • Graeme F. Woodworth
  • Rafael Tamargo
چکیده

Delayed cerebral ischemic injury secondary to vasospasm is a major cause of morbidity and mortality after subarachnoid hemorrhage (SAH) (28). Currently, there are no medical treatments that consistently prevent or reverse cerebral vasospasm. Recent studies suggest vasospasm is the result of a multifactorial process leading to a functional imbalance in the cerebrovascular smooth muscle tone (9, 10). Two potential etiologies include microvascular inflammatory cell infiltration and endothelial cell damage, both contributing to a subsequent deficiency of nitric oxide (NO) (6, 7).

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تاریخ انتشار 2014